Clinical Review  |   October 2018
Long-Term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease and Moderate Hypoxemia
Author Notes
  • From the Departments of Pulmonary and Critical Care (Dr Raza and Dr Wesselius) and Internal Medicine (Drs Nokes and Agrwal) at the Mayo Clinic in Phoenix, Arizona. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Neera Agrwal, MD, PhD, Mayo Clinic, Department of Internal Medicine, 5777 E Mayo Blvd, Phoenix, AZ 85054-4502. Email: agrwal.neera@mayo.edu
     
Article Information
Pulmonary Disorders
Clinical Review   |   October 2018
Long-Term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease and Moderate Hypoxemia
The Journal of the American Osteopathic Association, October 2018, Vol. 118, 663-665. doi:10.7556/jaoa.2018.145
The Journal of the American Osteopathic Association, October 2018, Vol. 118, 663-665. doi:10.7556/jaoa.2018.145
Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by chronic obstruction of lung airflow that interferes with normal breathing.1 It affects roughly 14% of the male and 7% of the female population globally,2 and it is the third-leading cause of death in the United States.3 The cost of COPD in the United States was projected to be $50 billion in 2010.4 Among patients with COPD in the United States, approximately 800,000 receive long-term oxygen therapy (LTOT).5 Long-term oxygen therapy has been widely accepted as a means to lower the mortality rate in patients with COPD, particularly in patients with severe hypoxemia.6 However, the mortality benefit of this therapy in patients with COPD with mild to moderate hypoxemia is unclear, with limited evidence for its use in the literature.7,8 

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